陈  震

个人概况

陈震, 博士，副教授，硕士生导师，主讲《发酵工程》、《酶工程》及《合成生物学》等课程，主要从事微生物发酵与代谢调控、食品酶制剂及合成生物学等方面的研究，主持国家自然科学基金、河南省高等学校重点科研项目、信阳师范大学博士科研启动基金各1项，参与完成国家自然科学基金面上项目2项。入选信阳师范大学“南湖青年学者（A类）”。以第一或通讯作者在Biotechnol. Adv., J. Agric. Food Chem. 及Biotechnol. Bioeng.等期刊上发表论文20余篇，授权国家发明专利7项，主编专著1部。

教育经历

2011年9月至2018年6月 厦门大学 生物化工专业  博士

2007年9月至2011年6月 南昌大学  生物工程专业  学士

工作经历

2025年1月至今                 信阳师范大学  茶学与食品学院    副教授

2024年7月至2024年12月  信阳师范大学  茶学与食品学院  讲师

2018年7月至2024年6月    信阳师范学院  生命科学学院  讲师

2021年7月至2023年7月    天津大学  化工学院  博士后

研究领域

1．微生物胞外聚合物合成过程与代谢调控机制

2．茶叶功能成分的生物合成及健康效应研究

3．食品酶制剂的研究及开发

工作介绍

1．基于多组学技术探究地衣芽孢杆菌合成胞外聚合物（多糖和聚谷氨酸）的生物合成过程及代谢调控机制。

2．基于代谢工程及合成生物学改造恶臭假单胞菌和酿酒酵母高效合成茶叶功能成分（茶氨酸及花青素等），并探究其健康效应机制。

3．基于宏基因组测序技术挖掘各类食品用酶（茶氨酸合成酶、单宁酶、果胶酶、漆酶）基因，用于食品酶制剂的研究及开发。

主持科研项目

1. 国家自然科学基金项目（22208276）， 地衣芽孢杆菌全局转录因子CcpA对γ-聚谷氨酸生物合成的调控机制, 30万，在研，主持

2. 河南省教育厅高等学校重点科研项目（23A416003），秸秆木质素发酵生产L-茶氨酸的高值化研究，3万元，在研，主持

3. 信阳师范大学A类博士科研启动基金项目（18156），代谢调控地衣芽孢杆菌提高γ-聚谷氨酸产量，10万元，在研，主持

发表高层次论文

第一或通讯作者论文

1. Zhen Chen※, He Liu※, Qiu-Jin Zong, Tianxin Liang, Jun Sun, Tao Xu, Zhi-Hua Liu*, JianpingWu, Bing-Zhi Li*, Ying-Jin Yuan, Engineering strategies enabled protocatechuic acid production from lignin by Pseudomonas putida KT2440, ACS Sustainable Chemistry Engineering, 2024, 12(49):17726-17738.（共同第一作者）

2. Zhen Chen※, Shilei Wang※, Zhichao Hui, Fei Wang, YuXin Ye, Yi He, Yanqing Li, Zhidan Yu, Yafan Cai, Wei Zhuang, Dong Liu, Zhi Wang*, Hanjie Ying, Sustainable production of extracellular polymeric substances and iron or copper complex from glutinous rice processing wastewater. Frontiers in Sustainable Food Systems, 2024, 8:1347500. (共同第一作者)

3. Zhen Chen, Xiaoning Liu*, Ali Basem, Dheyaa J. Jasim, Soheil Salahshour,  Shadi Esmaeili *. Investigating the effect of porosity on the adsorption of doxorubicin by bio-MOF-11 using molecular dynamics simulation. International Communications in Heat and Mass Transfer, 2024, 156: 107644. (第一作者)

4. Xiaoyu Wei, Lijie Yang, Zhen Chen*, Wenhao Xia, Yongbin Chen, Mingfeng Cao*, Ning He*. Molecular weight control of poly-γ-glutamic acid reveals novel insights into extracellular polymeric substance synthesis in Bacillus licheniformis. Biotechnology for Biofuels and Bioproducts, 2024, 17: 60. (共同通讯作者)

5. Zhipeng Li, Li You, Xiping Du, Haoyi Yang, Liang Yang, Yanbing Zhu, Lijun Li, Zedong Jiang, Qingbiao Li, Ning He, Rui Lin, Zhen Chen*, Hui Ni*. New strategies to study in depth the metabolic mechanism of astaxanthin biosynthesis in Phaffia rhodozyma. Critical Reviews in Biotechnology, 2024: 2344578.（共同通讯作者）

6. Zhen Chen, Menglei Wang, Yanyan Wu, Juzhong Tan, Zhipeng Li*. Editorial: High value utilization of waste in food processing. Frontiers in Sustainable Food Systems, 2024, 8:1423036 (第一作者)

7. Chen Zhen*, Zhang Shupei, Li Jialu, Du Wanying, Yang Mengyuan, Chen Dan. Insights into fermentation technology for traditional Chinese medicine: progress and applications. Animal Husbandry and Feed Science, 2024, 16(1-3): 32-41. (第一作者)

8. Zhen Chen*, Nada Othman Kattab. Silicon and titanium nanoparticles modulated drought and chromium toxicity by adjusting physio‑biochemical attributes and fatty acid profiles of black cumin (Nigella sativa L.). Environmental Science and Pollution Research, 2024, 31: 13563-13574. (第一作者)

9. Zhen Chen*, Menglei Wang, Wanxiang Ji. Novel fibromonas and fibrous microbial flocculant preparation and practical application. Journal of Biotech Research, 2024, 16:184-194. (第一作者)

10. Xiaoyu Wei, Zhen Chen*, Ailing Liu, Lijie Yang, Yiyuan Xu, Mingfeng Cao*, Ning He*. Advanced strategies for metabolic engineering of Bacillus to produce extracellular polymeric substances. Biotechnology Advances, 2023, 67(4): 108199. （共同通讯作者）

11. Zhen Chen*. Investigating the implementation of synthetic biology curricula in higher education within the framework of public health communities. Journal of Commercial Biotechnology, 2023, 28(6), 110–120. (唯一作者)

12. Zhen Chen※, Zhi Wang※, Hongyu Yuan, Ning He*. From tea leaves to factories: a review of research progress in L-theanine biosynthesis and production. Journal of Agriculture and Food Chemistry, 2021, 69(4): 1187-1196. （共同第一作者）

13. Wencheng Yu※, Zhen Chen※, Hong Ye, Peize Liu, Zhipeng Li, Yuanpeng Wang, Qingbiao Li, Shan Yan, Chuan-jian Zhong, Ning He*. Effect of glucose on poly-γ-glutamic acid metabolism in Bacillus licheniformis. Microbial Cell Factories, 2017, 16: 22. (共同第一作者)

14. Zhen Chen, Zhipeng Li, Peize Liu, Yu Liu, Yuanpeng Wang, Qingbiao Li, Ning He*. Characterization of a novel bioflocculant from a marine bacterium and its application in dye wastewater treatment. BMC Biotechnology, 2017, 17: 84. (第一作者)

15. Zhen Chen, Tong Meng, Zhipeng Li, Peize Liu, Yuanpen wang, Ning He*, Dafeng Liang*. Characterization of a beta-glucosidase from Bacillus licheniformis and its effect on bioflocculant degradation. AMB Express, 2017, 7: 197. (第一作者)

16. Zhen Chen, Peize Liu, Zhipeng Li, Wencheng Yu, Zhi Wang, Haosheng Yao, Yuanpeng Wang, Qingbiao Li, Xu Deng*, Ning He*. Identification of key genes involved in polysaccharide bioflocculant synthesis in Bacillus licheniformis. Biotechnology and Bioengineering, 2016, 114(3): 645-655. (第一作者)

17. 陈震*, 雷春香, 王梦蕾, 可欣. 发酵中药的研究及应用进展. 中国饲料, 2024，11: 147-154. (第一作者)

18. 陈震. 新工科背景下酶工程课程的研究性教学探索. 科技风，2023(24): 117⁃119. (唯一作者)

19. 陈震*, 苗馨, 孔明慧, 何梦凡, 张俊丽, 代亚峰. 发酵工程技术在食品添加剂领域的创新应用. 中国调味品, 2021, 46(5): 189-192. (第一作者)

其他论文

1.Yongbin Chen, Wenhao Xia, Fuping Lu, Zhen Chen, Yihan Liu*, Mingfeng Cao*, Ning He*. Cell-free synthesis system: An accessible platform from biosensing to biomanufacturing. Microbiological Research, 2025, 293: 128079.

2. He Liu, Zhen Chen, Jia-Qi Cui , Samuel Ntakirutimana, Tao Xu, Zhi-Hua Liu*, Bing-Zhi Li*, Ying-Jin Yuan. Funneling lignin hydrolysates into β-ketoadipic acid by engineered Pseudomonas putida KT2440. Industrial Crops and Products, 2024, 218:  118956.

3. Zhi Wang, Yanqing Li, Zhichao Hui, Jinle Liu, Xiaomin Guo, Zhen Chen, Zhidan Yu, Anqi Zhao, Shilei Wang, Yafan Cai, Ning He, Jingliang Xu*, Wei Zhuang*, Hanjie Ying. Biologically active selenium nanoparticles composited with Bacillus licheniformis extracellular polymeric substances fermented from cane molasses. LWT, 2023, 187: 115255.

4. Lijie Yang, Zhen Chen, Ying Zhang, Fuping Lu, Yihan Liu, Mingfeng Cao*, Ning He*. Hyperproduction of extracellular polymeric substance in Pseudomonas fluorescens for efficient chromium (VI) absorption. Bioresources and Bioprocessing, 2023, 10: 17.

5. Xiaoyu Wei, Lijie Yang, Haiyan Wang, Zhen Chen, Yiyuan Xu, Yue Weng, Mingfeng Cao, Qingbiao Li*, Ning He*. Genomic and metabolomic analysis of Bacillus licheniformis with enhanced poly-γ-glutamic acid production through atmospheric and room temperature plasma mutagenesis. Frontiers of Chemical Science and Engineering, 2022, 16: 1751–1760.

6.Yanyan Shi, Zhen Chen, Yixin Li, Xingyu Cao, Lijie Yang, Yiyuan Xu, Zhipeng Li, Ning He*. Function of ORFC of the polyketide synthase gene cluster on fatty acid accumulation in Schizochytrium limacinum SR21. Biotechnology for Biofuels, 2021, 14: 163.

7. Zhipeng Li, Zhen Chen, Hong Ye, Weiang Luo, Jo-Shu Zhang, Qingbiao Li, Ning He*. Anaerobic co-digestion of sewage sludge and food waste for hydrogen and VFA production with microbial community analysis. Waste Management, 2018, 78: 789-799.

8．Zhipeng Li, Xi Chen, Jun Li, Tong Meng, Lingwei Wang, Zhen Chen, Yanyan Shi, Xue-Ping Ling, Weiang Luo, Dafeng Liang, Yinghua Lu, Qingbiao Li, Ning He*. Functions of PKS genes in lipid synthesis of Schizochytrium sp. by gene disruption and metabolomics analysis. Marine Biotechnology, 2018, 9: 1-11.

9. Zhipeng Li, Tong Meng, Xueping Ling, Jun Li, Chuqiang Zheng, Yanyan Shi, Zhen Chen, Zhenqi Li, Qingbiao Li, Yinghua Lu, and Ning He*. Overexpression of malonyl-CoA: ACP transacylase in Schizochytrium sp. to improve polyunsaturated fatty acid production. Journal of Agricultural and Food Chemistry, 2018, 66(21): 5382-5391.

10. Zhi Wang, Zhen Chen, Lijie Yang, Fen Tan, Yuanpeng Wang, Qingbia Li, You-Im Chang, Chuan-jian Zhong, Ning He*. Effect of surface physicochemical properties on the flocculation behavior of Bacillus licheniformis. RSC Advances, 2017, 7(26): 16049-16056.

11. Peize Liu, Zhen Chen, Lijie Yang, Qingbiao Li, Ning He*. Increasing the bioflocculant production and identifying the effect of overexpressing epsB on the synthesis of polysaccharide and γ-PGA in Bacillus licheniformis. Microbial Cell Factories, 2017, 16: 163.

12. Wencheng Yu, Zhen Chen, Liang Shen, Yuanpeng Wang, Qingbiao Li, Shan Yan, Ning He*. Proteomics profiling of Bacillus licheniformis reveals a stress response mechanism in synthesis of extracelluar polymeric flocculants. Biotechnology and Bioengineering, 2016, 113(4): 797-806.

13. Shan Yan, Haosheng Yao, Zhen Chen, Shengquan Zeng, Xi Xi, Yuanpeng Wang, Qingbiao Li, Ning He*. Poly-γ-glutamic acid produced from Bacillus licheniformis CGMCC 2876 as a potential substitute for polyacrylamide in the sugarcane industry. Biotechnology Progress, 2015, 31(5): 1287-1294.

14. Shan Yan, Na Wang, Zhen Chen, Yuanpeng Wang, Ning He*, Yajuan Peng, Qingbiao Li, Xu Deng. Genes encoding the production of extracellular polysaccharide bioflocculant are clustered on a 30-kb DNA segment in Bacillus licheniformis. Functional and Integrative Genomics, 2013, 13(4): 425-434.

授权专利

1. 陈震，毛光志，王君一，孔明慧，韩冬，叶灿辉. 一种提高灵芝胞外多糖产量的方法，ZL202010901972.3

2. 陈震，代亚峰，苗馨，乔金贝，杨宁，曹文娅，苑美琪. 一种利用糯米加工废水制备生物絮凝剂的方法，ZL202010719370.6

联系方式

邮箱：chenzhen@xynu.edu.cn